Relevance

Relevance to the objectives of the FP6 programme
priority of life sciences and health

Functional genomics and proteomics will have a large impact on the practice of medicine of tomorrow. It is important that the EU invests into the basic research that will underpin this development towards predictive, personalized, and preventative medicine to secure a position that will allow the EU health care systems to receive the benefits of these new developments. The benefits are expected to be enormous in most disease areas and ranging in each of these areas from early diagnosis to the development of novel therapies for diseases that presently have no effective therapy and/or the improvement of known therapies. EuTRACC will result in the definition of TF networks on interactions that are expected to provide many new targets and pathways that form the basis for future translational research and ultimately application in the clinic. Thus in the longer term the basic research of this Integrated Project will have substantial socio-economic implications. The new approach aiming at functional protein complexes rather than the traditional individual protein targets is an innovative and very promising approach to achieve a gain in specificity for future clinical applications as only those targets of a complex will be affected by interference (usually one pathway) and not all pathways where a single factor might be involved.
The project will also have substantial technical implications as it aims to combine medium to high throughput approaches in proteomics, genomics and bio-informatics with a systems approach to arrive at a higher level of understanding of the regulation of stem cell maintenance and differentiation towards particular cell types. In the course of this project novel tagging and KO strategies will be applied in a systematic manner and provide a set of tools that can be generally applied to TF analysis.
 Lastly IP will be protected for future exploitation and the project will provide an excellent training environment for young researchers.  

Scientific objectives

  • This project aims to identify and model TF networks important for the maintenance or differentiation of embryonic totipotent cells to pluripotent or fully differentiated haematopoietic and neuronal cells.
  • This project will identify key functional TF interactions important for the generation of haematopoietic or neuronal stem cells or fully differentiated cells in culture.
  • This project will identify the binding sites of the TFs in the genome during the generation of haematopoietic or neuronal stem cells or fully differentiated cells in culture.
  • This project will provide the basis for future detailed investigations of a large number of TF by providing all the necessary tools.

This project will provide the technology for other proteins or networks of interacting proteins involved in other cellular processes. Novel proteins/genes discovered in this program will be functionally analysed, annotated and modeled into networks.

Technical objectives 

  • This project will provide novel rapid and cost effective technology to carry out TF proteomics and functional genomics and model this into TF networks.
  • This project will provide mice carrying conditional KO alleles for a large number of TFs or associated proteins.
  • The technology developed in this project can be applied to any other protein/gene.

Societal objectives

  • The Intellectual Property developed in this project is and will be protected for exploitation by the SME with the aim to provide economic benefits in the future.
  • The project will further enhance the competitive position of Europe in this area.
  • This project aims to provide gene targets leading to novel therapeutics, biologics, medicinal chemistry targets and diagnostics/prognostics.
  • The project will provide excellent training facilities for young researchers using proteomics, genomics and bio-informatics.
  • The consortium will have a public website to allow the public and policy makers to follow developments. In particular the application of proteomics and genomics technology to the identification and subsequent analysis of genes and gene pathways. A number of these will impinge on haematopoietic and neuronal disease processes.
  • The consortium will make the ES cell resources available via posting on the website and publication in peer reviewed journals.

 

 
EuTRACC
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