Name:
Rein Aasland
Email:
aasland@mbi.uib.no
Affiliation:
13 Universitetet i Bergen, Bergen, Norway.
Website:
http://www.uib.no/mbi/aasland/

Rein Aasland is a Senior Scientist and Group Leader at the Computational Biology Unit (CBU) and full professor at the Department of Molecular Biology, University of Bergen. Aasland's research is focused on nucleosome-binding proteins and protein domains involved in epigenetic gene regulation and his group studies them both experimentally and bioinformatically. Current research is focussed on how protein domains that modify histones interact and communicate with domains that recognise the histone modifications. Aasland was partner and scientific co-cordinator of the EU-funded ELM project for development of a computational resource for prediction of functional linear motifs in proteins (the ELM resource: http://elm.eu.org). In this project, Aasland is particularly interested in linear motifs in transcription factors and chromatin proteins and how they mediate interactions in regulatory networks.

- Puntervoll, P., Linding, R., Gemünd, C., Chabanis-Davidson, S., Mattingsdal, M., Cameron, S., Martin, D.A., Ausiello, G., Brannetti, B., Costantini, A., Ferrè, F., Maselli, V., Via, A., Cesareni, G., Diella, F., Superti-Furga, G., Wyrwicz, L., Ramu, C., McGuigan, C., Gudavalli, R., Letunic, I., Bork, P., Rychlewsji, L., Küster, B., Helmer-Citterich, M., Hunter, W.N., Aasland, R., Gibson, T.J. (2003) The ELM server: A new resource for revealing short functional sites in modular eukaryotic proteins. Nucl. Acids Res. 31, 3625-3630.
- Ragvin, A., Valvatne, H., Erdal, S., Årskog, V., Tufteland, K.R., Breen, K., Øyan, A.M., Eberharter, A., Gibson, T.J., Becker, P.B., and Aasland R., (2004) The PHD finger of the transcriptional coactivator p300 binds nucleosomes in vitro. J. Mol. Biol. 337, 773-788
- Roguev, A., Schaft, D., Shevchenko, A., Aasland, R., Shevchenko, A. and Stewart, A.F. (2003) High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. J Biol Chem, 278, 8487-8493
- Korenjak, M., Taylor-Harding, B., Binne, U.K., Satterlee, J.S., Stevaux, O., Aasland, R., White-Cooper, H., Dyson, N., Brehm, A. (2004). Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell, 119, 181-193.
- Glaser, S., Schaft, J., Lubitz, S., Vintersten, K., van der Hoeven, F., Tufteland, K.R., Aasland, R., Anastassiadis, K., Ang, S.L., and Stewart, A.F. (2006). Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development. 133, 1423-1432.